THE ROLE OF SMALL GTP-BINDING PROTEINS IN LEUKOCYTE FUNCTION

被引：38

作者：

BOKOCH, GM ^{[1
]}

KNAUS, UG ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CELL BIOL, LA JOLLA, CA 92037 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 01期

关键词：

D O I：

10.1016/0952-7915(94)90040-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent progress in understanding the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) provides the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year indicate that the activity of NADPH oxidase can be modulated by regulation of the GTP- versus GDP-bound state of Rac. Additional proteins of the Ras superfamily are likely to be involved in a variety of normal leukocyte functions.

引用

页码：98 / 105

页数：8

共 56 条

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