PLACENTAL VASCULAR MALFORMATION WITH MESENCHYMAL HYPERPLASIA AND A LOCALIZED CHORIOANGIOMA

We here report a case of placental vascular malformation with mesenchymal hyperplasia of the villi and a localized chorioangioma. After an uneventful pregnancy our delivered a non-malformed live female infant. The placenta was grossly enlarged, and macroscopically it was characterized by strongly enlarged varicous chorionic vessels. On the maternal plate vesicle-like structures, giving the impression of partial mole, were seen. At microscopy level, areas of normal looking tissue alternated with areas of excessively enlarged villi, in which the ground substance contained large amounts of acid mucopolysaccharide, corresponding to ''mesenchymal hyperplasia''. Moreover, a localized chorioangioma was found. In none of the histological sections were cisterns, abnormal trophoblastic proliferation, stunted ramification or stromal trophoblastic inclusions observed. In week 15 maternal se-AFP was elevated to 3.03 multiples of the median. Genetic analysis revealed a normal female karyotype and biparental genomic contributions to a winked loci. Placental vascular malformation with mesenchymal hyperplasia is different diagnosis to partial mole should be considered placental enlarge is observed along with living fetus.