THE PREDICTION OF DRUG SOLUBILITIES IN POLYMERS

被引：13

作者：

BAO, YT ^{[1
]}

SAMUEL, NKP ^{[1
]}

PITT, CG ^{[1
]}

机构：

[1] RES TRIANGLE INST,POB 12194,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF POLYMER SCIENCE PART C-POLYMER LETTERS | 1988年 / 26卷 / 01期

关键词：

DRUG PRODUCTS - Controlled Delivery - SOLUTIONS - Mathematical Models;

D O I：

10.1002/pol.1988.140260106

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We have recently discussed the correlation of octanol-water and polymer-water partition coefficients and the use of such correlations as a tool to estimate solubilities in polymers. The correlation permits determination of the relative solubilities of a solute in different polymers as a function of solute lipophilicity; when combined with the aqueous solubility of the solute, it may be used to estimate absolute solubilities in polymers. This ability to estimate relative and absolute solubilities is useful in such technologies as membrane separations, drug delivery, and polymer packaging. In this letter, we report more complete correlation data, analysis of which shows that the slope of the correlation equation for six polymers is proportional to the solubility parameter of the polymer, while the intercept can be derived from the solubility of water in the polymer bulk.

引用

页码：41 / 46

页数：6

共 19 条

[1] METHOD FOR ESTIMATING BOTH SOLUBILITY PARAMETERS AND MOLAR VOLUMES OF LIQUIDS [J].