NOVEL ENZYMATIC PRODUCTION OF D-(-)-PANTOYL LACTONE THROUGH THE STEREOSPECIFIC REDUCTION OF KETOPANTOIC ACID

被引：25

作者：

KATAOKA, M

SHIMIZU, S

YAMADA, H

机构：

[1] Department of Agricultural Chemistry, Kyoto University, Kyoto

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1990年 / 54卷 / 01期

关键词：

D O I：

10.1080/00021369.1990.10869925

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The high yield stereoselective reduction of ketopantoic acid to D-(−)-pantoic acid with microbial cells as a catalyst is described. High activity was found in several bacteria belonging to the genus Agrobacterium. On incubation with a soil isolate, Agrobacterium sp. S-246, the yield of D-(−)-pantoic acid reached 119 mg/ml, with high molar conversion (90 %) and high stereoselectivity (> 98% enantiomeric excess). Ketopantoic acid reductase (EC 1.1.1.169) was suggested to be the enzyme responsible for this conversion. © 1990 by the Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.

引用

页码：177 / 182

页数：6

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