PENTOBARBITAL-ANESTHESIA PREVENTS THE ADRENALINE-RELEASING EFFECT OF THE 5-HT1A RECEPTOR AGONIST, 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN

被引：12

作者：

CHAOULOFF, F

BAUDRIE, V

LAUDE, D

机构：

[1] Laboratoire de Pharmacologie, Groupe de Neuropharmacologie, CNRS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 01期

关键词：

5-HT[!sub]1A[!/sub] receptors; 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; Adrenaline; Glucemia; Pentobarbital anaesthesia;

D O I：

10.1016/0014-2999(90)90606-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Administration of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.25 mg/kg i.v.), to conscious rats increased plasma adrenaline and glucose levels for 30 and 60 min, respectively. Both 8-OH-DPAT-induced changes in plasma adrenaline and glucose levels were totally abolished in pentobarbital-anaesthetized rats. The present data indicate that pentobarbital anaesthesia, a procedure that is commonly used in pharmacological studies, prevents the release of adrenaline evoked by 5-HT1A receptor activation. © 1990.

引用

页码：175 / 178

页数：4

共 10 条

[1] MARKED INCREASES IN PLASMA-CATECHOLAMINE CONCENTRATIONS PRECEDE HYPOTENSION AND BRADYCARDIA CAUSED BY 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN (8-OH-DPAT) IN CONSCIOUS RATS [J].