5,7-DIHYDROXYTRYPTAMINE INJECTIONS INCREASE GLIAL FIBRILLARY ACIDIC PROTEIN IN THE HYPOTHALAMUS OF ADULT-RATS

被引：25

作者：

FRANKFURT, M

OCALLAGHAN, J

BEAUDET, A

机构：

[1] US EPA,HLTH EFFECTS RES LAB,RES TRIANGLE PK,NC 27711

[2] MONTREAL NEUROL HOSP & INST,NEUROANAT LAB,MONTREAL H3A 2B4,QUEBEC,CANADA

来源：

BRAIN RESEARCH | 1991年 / 549卷 / 01期

关键词：

ASTROCYTE; HYPOTHALAMUS; SEROTONIN; 5,7-DIHYDROXYTRYPTAMINE; VENTROMEDIAL;

D O I：

10.1016/0006-8993(91)90609-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution and levels of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxin, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. In addition, levels of GFAP were significantly increased 7 days after 5,7-DHT injection.

引用

页码：138 / 140

页数：3

共 16 条

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