IDENTIFICATION OF AN ESSENTIAL DROSOPHILA GENE THAT IS HOMOLOGOUS TO THE TRANSLATION INITIATION FACTOR-EIF-4A OF YEAST AND MOUSE

被引：41

作者：

DORN, R ^{[1
]}

MORAWIETZ, H ^{[1
]}

REUTER, G ^{[1
]}

SAUMWEBER, H ^{[1
]}

机构：

[1] UNIV COLOGNE,INST ENTWICKLUNGSBIOL,W-5000 COLOGNE,GERMANY

来源：

MOLECULAR & GENERAL GENETICS | 1993年 / 237卷 / 1-2期

关键词：

DROSOPHILA-MELANOGASTER; TRANSLATION; INITIATION FACTOR; ESSENTIAL GENE;

D O I：

10.1007/BF00282805

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene encoding a protein homologous to the translation initiation factor eIF-4A in mouse has been identified in Drosophila melanogaster. The predicted amino acid sequence shows 73% identity with the mouse gene and 67% identity with a homologous protein from yeast. The single-copy Drosophila gene is located on chromosome arm 2L at 26A7-9. Several recessive lethal mutations have been isolated and genetically characterized. Northern blot hybridization shows two abundant transcripts of 1.75 kb and 1.9 kb throughout all developmental stages. Both transcripts are maternally provided to the oocyte.

引用

页码：233 / 240

页数：8

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