IN-VITRO SUSCEPTIBILITY OF BORRELIA-BURGDORFERI TO 11 ANTIMICROBIAL AGENTS

被引:42
作者
LEVIN, JM
NELSON, JA
SEGRETI, J
HARRISON, B
BENSON, CA
STRLE, F
机构
[1] RUSH MED COLL,INFECT DIS SECT,CHICAGO,IL 60612
[2] RUSH MED COLL,DEPT MED TECHNOL,CHICAGO,IL 60612
[3] UNIV LODZ,MED CTR,PL-90131 LODZ,POLAND
关键词
D O I
10.1128/AAC.37.7.1444
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro susceptibility of Borrelia burgdorferi to 11 antimicrobial agents was investigated. The antimicrobial agents evaluated included ceftizoxime, FK037, cefotaxime, dirithromycin, clarithromycin and its metabolite 14-hydroxy-clarithromycin, erythromycin, doxycycline, amoxicillin, ciprofloxacin, and ofloxacin. Isolates of B. burgdorferi tested included two reference strains (B31 and ATCC 53899), six isolates from the midwestern United States, and three from Europe. A broth macrodilution method was used to determine MICs and MBCs. B. burgdorferi was inhibited by less-than-or-equal-to 0.5 mug of each of the agents except the quinolones per ml. The MBCs for 90% of strains tested of ceftizoxime, FK037, clarithromycin, 14-OH clarithromycin, and dirithromycin (less-than-or-equal-to 1.0 mug of each per ml) were superior to those of amoxicillin (2.0 mug/ml) and doxycycline (4.0 mug/ml). Further in vivo studies are warranted to determine whether these agents may be efficacious in the treatment of Lyme borreliosis.
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页码:1444 / 1446
页数:3
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