SUPPRESSION OF RADIATION-INDUCED NEOPLASTIC TRANSFORMATION BY OVEREXPRESSION OF MITOCHONDRIAL SUPEROXIDE-DISMUTASE

被引：140

作者：

STCLAIR, DK

WAN, XS

OBERLEY, TD

MUSE, KE

STCLAIR, WH

机构：

[1] UNIV KENTUCKY, ALBERT B CHANDLER MED CTR, LEXINGTON, KY 40536 USA

[2] UNIV WISCONSIN, DEPT PATHOL, MADISON, WI 53706 USA

[3] UNIV WISCONSIN, VA HOSP, MADISON, WI 53706 USA

来源：

MOLECULAR CARCINOGENESIS | 1992年 / 6卷 / 04期

关键词：

MITOCHONDRIA; SUPEROXIDE DISMUTASE; NEOPLASTIC TRANSFORMATION; IONIZING RADIATION;

D O I：

10.1002/mc.2940060404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation.

引用

页码：238 / 242

页数：5

共 25 条

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