RETRACTED: CERULOPLASMIN GENE DEFECT ASSOCIATED WITH EPILEPSY IN EL MICE (RETRACTED ARTICLE. SEE VOL 11, PG 104, 1995)

被引：21

作者：

GAREY, CE ^{[1
]}

SCHWARZMAN, AL ^{[1
]}

RISE, ML ^{[1
]}

SEYFRIED, TN ^{[1
]}

机构：

[1] BOSTON COLL, DEPT BIOL, CHESTNUT HILL, MA 02167 USA

来源：

NATURE GENETICS | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1038/ng0494-426

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epilepsy is a dominant trait in EL mice, a model for human complex partial seizures. We recently mapped the major gene, El-1, to chromosome 9 near the predicted location for the ceruloplasmin (Cp) gene. We now present evidence for a partial duplication in the Cp gene in EL mice. This Cp duplication is coinherited with seizures in backcross generations and is associated with enhanced expression of Cp mRNA and increased Cp oxidase activity. Moreover, the duplication is associated with an enhanced frequency of double recombinants, simulating negative interference. The findings are relevant to the basic mechanisms of epilepsy and to theories of genetic recombination and gene mapping.

引用

页码：426 / 431

页数：6

共 48 条

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