SPECIFIC INCREASE OF L-DOPA LEVELS IN PLASMA UPON INFUSION OF TRYOSINASE CONTAINING LIPOSOMES

被引：7

作者：

MIRANDA, M ^{[1
]}

AMICARELLI, F ^{[1
]}

VOLPE, AR ^{[1
]}

POMA, A ^{[1
]}

MASCIOCCO, L ^{[1
]}

CARMIGNANI, M ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE, I-00168 ROME, ITALY

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1993年 / 24卷 / 06期

关键词：

D O I：

10.1016/0306-3623(93)90413-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The present paper reports the effects of liposome-entrapped tyrosinase (EC 1.14.18.1. L-Tyrosine, L-3,4-dihydroxyphenylalanine: oxygen oxidoreductase) infusion on the catecholamine contents of rat plasma. The actions of liposomes and free tyrosinase have also been investigated. 2. From the experiments, evidence has been obtained that liposome-entrapped tyrosinase is able to affect specifically L-3,4-dihydroxyphenylalanine (L-DOPA) levels which increase dramatically. 3. The possible use of liposome-entrapped tyrosinase to raise L-DOPA levels in catecholamine related disorders is discussed. 4. Liposomes without tyrosinase provoke no significant changes of catecholamine or L-DOPA levels while free tyrosinase does induce a change but in a less constant fashion than the liposome-entrapped enzyme.

引用

页码：1319 / 1322

页数：4

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