COMPUTER-SIMULATIONS TO PREDICT THE AVAILABILITY OF PEPTIDES WITH KNOWN HLA CLASS-I MOTIFS POSSIBLY GENERATED BY PROTEOLYSIS OF HIV-1 PROTEINS IN INFECTED-CELLS

被引：5

作者：

BECKER, Y

机构：

[1] Department of Molecular Virology, Institute of Microbiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem

来源：

VIRUS GENES | 1995年 / 10卷 / 03期

关键词：

HIV-1; PROTEINS; COMPUTER ANALYSIS; PROTEASOME PROTEOLYSIS; PROTEOLYTIC CLEAVAGE OF HIV-1 PROTEINS; SIGNAL PEPTIDASE; NONAMERIC HIV-1 PEPTIDES; HLA CLASS I HAPLOTYPES;

D O I：

10.1007/BF01701812

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cytotoxic T cells that recognize HIV-1 peptides generated from all viral proteins were reported. To predict the cleavage pattern of HIV-1 proteins by cytoplasmic proteasomes into peptides with motifs fitting known HLA class I molecules, the computer program Findpatterns was used. In this paper the combined amino acids patterns for proteolytic cleavages and the HLA class I haplotype-restricted peptides motifs are studied. It was noted that peptides with motifs of HLA class I A2 and A68 were abundant compared with HLA class 5B2, B8, B53, and B35.

引用

页码：227 / 237

页数：11

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