NALIDIXIC-ACID CAUSES A TRANSIENT G1 ARREST IN THE YEAST SACCHAROMYCES-CEREVISIAE

被引：13

作者：

SINGER, RA

JOHNSTON, GC

机构：

[1] DALHOUSIE UNIV,DEPT BIOCHEM,HALIFAX B3H 4H7,NS,CANADA

[2] DALHOUSIE UNIV,DEPT MICROBIOL,HALIFAX B3H 4H7,NS,CANADA

来源：

MOLECULAR & GENERAL GENETICS | 1979年 / 176卷 / 01期

关键词：

D O I：

10.1007/BF00334293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of nalidixic acid to growing cells of the yeast Saccharomyces cerevisiae resulted in a transient depression in the rate of ribosomal precursor RNA production and a transient arrest of cells in G1. Protein synthesis rates were less affected. Lower concentrations of nalidixic acid also affected RNA synthesis and progression through G1 but had no effect on protein synthesis rates. We suggest that nalidixic acid has a primary effect on RNA synthesis leading to a G1 arrest. © 1979 Springer-Verlag.

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页码：37 / 39

页数：3

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