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PSYCHOENDOCRINE MODEL OF DEPRESSION

被引：26
作者：
HATOTANI, N
NOMURA, J
INOUE, K
KITAYAMA, I
机构：
[1] Department of Psychiatry, School of medicine, Mie University, Tsu, Mie-ken
来源：
PSYCHONEUROENDOCRINOLOGY | 1979年 / 4卷 / 02期
关键词：
brain monoamines; hypothalamic dysfunction; neuroendocrine model of depression;
D O I：
10.1016/0306-4530(79)90029-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
(1) Hypothalamo-pituitary dysfunction appears to be the most significant finding of neuroendocrine studies of depression. (2) The underlying pathology of this dysfunction is probably a metabolic disturbance of brain monoamines. (3) Brain monoamines were examined by the fluorescence histochemical method in a stress-induced animal model of depression. (4) An increase in fluorescence intensity was found in the cell groups of the ascending NA system. (5) Cell bodies and nerve terminals of the tubero-infundibular DA system showed a decrease of fluorescence intensity. (6) The turnover rate of catecholamines in nerve terminals of the ascending NA system decreased. © 1979.
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页码：155 / 172
页数：18
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