DISTURBANCES OF ESSENTIAL FATTY ACID-MEDIATED AND PROSTAGLANDIN-E-MEDIATED IMMUNOREGULATION IN ATOPY

被引：14

作者：

MELNIK, BC ^{[1
]}

PLEWIG, G ^{[1
]}

TSCHUNG, T ^{[1
]}

机构：

[1] ANALYT LAB, W-5000 COLOGNE 50, GERMANY

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1991年 / 42卷 / 02期

关键词：

D O I：

10.1016/0952-3278(91)90079-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Impaired suppressor T lymphocyte maturation and function in atopic individuals are explained by an insufficient transmission of prostaglandin E (PGE) signals during thymic lymphocyte differentiation as well as an impaired ability of the atopic immune system to activate suppressor T-cells by PGE-mediated feed back mechanisms. We demonstrate that spontaneous in vitro immunoglobulin E synthesis of atopic peripheral blood mononuclear cells could be suppressed by the addition of 10(-6) M to 10(-5) M PGE1 or PGE2. Decreased plasma and breast milk levels of PGE-precursor fatty acids and reduced numbers of PGE2-receptors on atopic lymphocytes have been observed in atopic individuals. These insights might offer a novel approach for the prevention of atopic disease by substitution of the atopic pregnant and nursing woman and her newborn infant with long chain omega-6-fatty acids.

引用

页码：125 / 130

页数：6

共 56 条

[1] CYCLIC-AMP AS THE 2ND MESSENGER FOR PROSTAGLANDIN-E IN MODULATING SUPPRESSOR CELL-ACTIVATION BY NATURAL SUPPRESSOR CYTOTOXIC-CELLS [J].