EFFECTS OF INDOMETHACIN ON DEMINERALIZED BONE-INDUCED HETEROTOPIC OSSIFICATION IN THE RAT

被引：30

作者：

DICESARE, PE ^{[1
]}

NIMNI, ME ^{[1
]}

PENG, L ^{[1
]}

YAZDI, M ^{[1
]}

CHEUNG, DT ^{[1
]}

机构：

[1] UNIV SO CALIF, HOSP ORTHOPAED,SCH MED, BONE & CONNECT TISSUE BIOCHEM RES LAB, 2400 S FLOWER ST, LOS ANGELES, CA 90007 USA

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1991年 / 9卷 / 06期

关键词：

DEMINERALIZED BONE MATRIX; HETEROTOPIC OSSIFICATION; INDOMETHACIN; INFLAMMATION;

D O I：

10.1002/jor.1100090611

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Indomethacin inhibits bone formation when treatment is initiated before the implantation of demineralized bone matrix (DBM). For the inhibition of bone induction to occur, indomethacin treatment had to be initiated 6 h or more before implantation of DBM. Initiating the drug treatment at or after the time of DBM implantation had no effects on the amounts of new bone formed. The inhibition by indomethacin is dose related over a range between 0.04 and 4 mg/kg body weight. Recovered day-1 DBM implants, transplanted into indomethacin pre- and posttreated syngeneic rats, formed bone at the same rate as controls did. However, recovered day-1 DBM implants lyophilized before transplantation showed decreased bone formation but significant dystrophic calcification as judged by a lower alkaline phosphatase activity and an elevated calcium content.

引用

页码：855 / 861

页数：7

共 27 条

[1] THE MECHANISMS OF ACTION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].