D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS

被引：82

作者：

OZER, NK

PALOZZA, P

BOSCOBOINIK, D

AZZI, A

机构：

[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, BUHLSTR 28, CH-3012 BERN, SWITZERLAND

[2] MARMARA UNIV, FAC MED, DEPT BIOCHEM, 81326 HAYDARPASA, TURKEY

[3] UNIV CATTOLICA SACRO CUORE, IST PATOL GEN, I-00168 ROME, ITALY

来源：

FEBS LETTERS | 1993年 / 322卷 / 03期

关键词：

SMOOTH MUSCLE CELL PROLIFERATION; D-ALPHA-TOCOPHEROL; ARTERIOSCLEROSIS; LOW DENSITY LIPOPROTEIN;

D O I：

10.1016/0014-5793(93)81592-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.

引用

页码：307 / 310

页数：4

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