SUPPRESSIVE EFFECT OF AN ORAL SORBENT ON THE ACCUMULATION OF P-CRESOL IN THE SERUM OF EXPERIMENTAL UREMIC RATS

被引：54

作者：

NIWA, T ^{[1
]}

ISE, M ^{[1
]}

MIYAZAKI, T ^{[1
]}

MEADA, K ^{[1
]}

机构：

[1] KUREHA CHEM IND CO LTD,TOKYO,JAPAN

来源：

NEPHRON | 1993年 / 65卷 / 01期

关键词：

P-CRESOL; PHENOL; UREMIA; ORAL SORBENT; AST-120;

D O I：

10.1159/000187446

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Serum p-cresol and phenol are markedly accumulated in uremic patients. To determine if an oral sorbent (AST-120) can decrease their serum concentrations in the uremic state, an oral sorbent was administered to experimental nephrectomized uremic rats. In uremic rats fed with oral sorbent, the serum concentration and the urinary excretion of p-cresol were markedly and significantly lower than those in control uremic rats, while those of phenol tended to be low in the uremic rats with oral sorbent as compared with control uremic rats. The concentrations of serum creatinine and blood urea nitrogen were significantly decreased in the uremic rats with oral sorbent. These findings demonstrate that oral sorbent adsorbs especially p-cresol in the intestine and prevents the accumulation of p-cresol in the serum of uremic rats.

引用

页码：82 / 87

页数：6

共 22 条

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