EXPERIMENTAL-DESIGN APPROACH FOR SUPERCRITICAL FLUID EXTRACTION

被引：29

作者：

KANE, M

DEAN, JR

HITCHEN, SM

DOWLE, CJ

TRANTER, RL

机构：

[1] UNIV NORTHUMBRIA,DEPT CHEM & LIFE SCI,ELLISON BLDG,NEWCASTLE TYNE NE1 8ST,ENGLAND

[2] ICI PLC,WILTON RES CTR,MIDDLESBROUGH TS6 8JE,CLEVELAND,ENGLAND

[3] GLAXO MFG SERV,DURHAM DL12 8DT,ENGLAND

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 271卷 / 01期

关键词：

CARBON DIOXIDE; EXTRACTION; MULTILINEAR REGRESSION; STEROIDS; SUPERCRITICAL FLUID EXTRACTION;

D O I：

10.1016/0003-2670(93)80555-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Experimental design with multilinear regression has been used to examine the relative contribution of the main experimental variables during supercritical fluid extraction. Six steroidal compounds of various solubilities in supercritical CO2 were considered. The results indicate that the density of the supercritical fluid has the greatest effect on the solubilisation and transfer of steroid from extraction cell to collection device. The minimum number of cell volumes of supercritical CO2 required for effective extraction was experimentally determined.

引用

页码：83 / 90

页数：8

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