HIGH-FREQUENCY OF HUMAN PAPILLOMAVIRUS DETECTION IN URINARY-BLADDER CANCER

被引：36

作者：

AGLIANO, AM

GRADILONE, A

GAZZANIGA, P

NAPOLITANO, M

VERCILLO, R

ALBONICI, L

NASO, G

MANZARI, V

FRATI, L

VECCHIONE, A

机构：

[1] Department of Experimental Medicine, University of Rome ‘La Sapienza’, Rome

[2] Department of Experimental Medicine and Biochemical Sciences, University of Rome ‘Tor Vergata’, Rome

来源：

UROLOGIA INTERNATIONALIS | 1994年 / 53卷 / 03期

关键词：

PAPILLOMAVIRUS; HUMAN; CARCINOMA; POLYMERASE CHAIN REACTION;

D O I：

10.1159/000282652

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.

引用

页码：125 / 129

页数：5

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