BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION

The absorption and elimination of pralidoxime salts after oral administration to human volunteers have been studied at a dosage of 1.5–10 g. of drug for a 70‐kg. man. The biological half‐life, calculated from blood plasma values and urinary excretion rates, was approximately 1.7 hr. A 10‐fold increase in dosage of the pralidoxime salts increased the peak plasma level of oxime 3.5‐fold. The average total amount of pralidoxime recovered in the urine was 27 percent. In subjects given the iodide salt, symptoms of iodism were observed; all other clinical tests were negative. Some observations were made on the behavior of a bis‐quaternary oxime. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company