EXPRESSION OF THE MYELOID DIFFERENTIATION ANTIGEN CD33 DEPENDS ON THE PRESENCE OF HUMAN-CHROMOSOME 19 IN HUMAN-MOUSE HYBRIDS

被引：4

作者：

ADRIAANSEN, HJ ^{[1
]}

VANKESSEL, AHMG ^{[1
]}

WIJDENESDEBRESSER, JHFM ^{[1
]}

VANDRUNENSCHOENMAKER, E ^{[1
]}

VANDONGEN, JJM ^{[1
]}

机构：

[1] ERASMUS UNIV, DEPT CELL BIOL & GENET, 3000 DR ROTTERDAM, NETHERLANDS

来源：

ANNALS OF HUMAN GENETICS | 1990年 / 54卷

关键词：

D O I：

10.1111/j.1469-1809.1990.tb00367.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interlineage human‐mouse hybrids were constructed by fusion of human acute undifferentiated leukaemia cells with the mouse thymoma cell line BW5147. Some of the hybrids expressed the human differentiation antigens CD4, CD7, CD33, and CD71 (transferrin receptor). Chromosome analysis revealed that the expression of the myeloid antigen CD33 is dependent on the presence of human chromosome 19, which is in agreement with the location of CD33‐coding sequences on chromosome 19, as recently reported by Peiper et al. (1987). Furthermore, these hybrids allowed us to confirm the assignment of the CD4 antigen, the CD7 antigen, and the CD71 antigen to human chromosomes 12, 17 and 3, respectively. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：115 / 119

页数：5

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