DIFFERENTIAL EFFECTS OF FIBROBLAST AND LEUKOCYTE INTERFERON IN HBSAG POSITIVE CHRONIC ACTIVE HEPATITIS

被引：28

作者：

WEIMAR, W ^{[1
]}

HEIJTINK, RA ^{[1
]}

SCHALM, SW ^{[1
]}

SCHELLEKENS, H ^{[1
]}

机构：

[1] ERASMUS UNIV,DEPT VIROL,NL-3000 DR ROTTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 9卷 / 02期

关键词：

chronic active hepatitis; Fibroblast interferon; leucocyte interferon;

D O I：

10.1111/j.1365-2362.1979.tb01682.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. Six patients with hepatitis B surface antigen, hepatitis B ‘e’ antigen positive chronic active hepatitis, and elevated hepatitis B specific DNA polymerase activity were treated sequentially with fibroblast and leucocyte interferon. Fibroblast interferon induced a fall in serum transaminase activities in all patients, whereas a consistent decline in DNA polymerase activity was observed during leucocyte interferon administration only. After treatment one patient remained persistently DNA polymerase and hepatitis B ‘e’ antigen negative, whereas relapse to initial values occurred in others. Side effects included severe but reversible granulocytopenia, and chills responding to promethazine treatment. The differential biological activity of fibroblast and leucocyte interferon in our patients coincides with their non‐identity in in vitro studies. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：151 / 154

页数：4

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