3-DIMENSIONAL MODELS OF THE GDP AND GTP FORMS OF THE GUANINE-NUCLEOTIDE DOMAIN OF ESCHERICHIA-COLI ELONGATION FACTOR-TU

Three-dimensional models of the GDP and GTP forms of the guanine nucleotide domain of Escherichia coli elongation factor Tu have been derived from the atomic coordinates of the trypsin-modified form of EF-Tu-GDP and by comparison with the ras p21 structures. The significance of the differences in the guanine nucleotide binding sites of EF-Tu and ras p21 are discussed. Crystallization of the EF-Tu-GMPPNP complex is reported. © 1990.