INTERFERENCE OF POLYCHLORINATED-BIPHENYLS IN THYROID-HORMONE METABOLISM - POSSIBLE NEUROTOXIC CONSEQUENCES IN FETAL AND NEONATAL RATS

被引：23

作者：

MORSE, DC ^{[1
]}

KOETER, HBWM ^{[1
]}

VANPROOIJEN, AES ^{[1
]}

BROUWER, A ^{[1
]}

机构：

[1] INST NUTR & TOXICOL,ZEIST,NETHERLANDS

来源：

CHEMOSPHERE | 1992年 / 25卷 / 1-2期

关键词：

D O I：

10.1016/0045-6535(92)90504-K

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Prenatal administration of 3,3', 4,4', 5,5'-hexachlorobiphenyl (HCB) and 3,3',4,4'-tetrachlorobiphenyl (TCB) resulted in decreased plasma thyroid hormones and altered thyroid hormone metabolism in brain homogenates of pregnant Wistar WU rats, their fetusses and their offspring. These effects of HCB and TCB occur at a time when thyroid hormones play a crucial role in neurological development.

引用

页码：165 / 168

页数：4

共 8 条

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