THE THERMODYNAMIC EFFECTS OF PROTEIN MUTATIONS

被引：83

作者：

STURTEVANT, JM

机构：

[1] Department of Chemistry, Yale University, New Haven, CT 00511-1118

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(94)90062-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of cloning procedures has made possible a rapid increase in the appearance of reports on the thermodynamic effects of mutations in proteins. It will be helpful if the availability of excellent calorimetric instrumentation leads to an increase in the fraction of these studies directed toward the determination of enthalpies and entropies as well as free energies.

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页码：69 / 78

页数：10

相关论文

共 62 条

[1]

ALLOCATELLI CT, 1993, BIOCHEMISTRY-US, V32, P6041

[2] THERMAL-DENATURATION OF BACTERIOPHAGE-T4 LYSOZYME AT NEUTRAL PH [J].

BECKTEL, WJ ;

BAASE, WA .

BIOPOLYMERS, 1987, 26 (05) :619-623

[3] DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF 6 AMINO-ACID SUBSTITUTIONS AT THR 59 [J].

BELL, JA ;

BECKTEL, WJ ;

SAUER, U ;

BAASE, WA ;

MATTHEWS, BW .

BIOCHEMISTRY, 1992, 31 (14) :3590-3596

[4] DETERMINATION OF A HIGH-QUALITY NUCLEAR-MAGNETIC-RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN-INHIBITOR AND COMPARISON WITH 3 CRYSTAL-STRUCTURES [J].

BERNDT, KD ;

GUNTERT, P ;

ORBONS, LPM ;

WUTHRICH, K .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 227 (03) :757-775

[5] DESIGNED REPLACEMENT OF AN INTERNAL HYDRATION WATER MOLECULE IN BPTI - STRUCTURAL AND FUNCTIONAL IMPLICATIONS OF A GLYCINE-TO-SERINE MUTATION [J].

BERNDT, KD ;

BEUNINK, J ;

SCHRODER, W ;

WUTHRICH, K .

BIOCHEMISTRY, 1993, 32 (17) :4564-4570

[6] THE ROLE OF TURNS IN THE STRUCTURE OF AN ALPHA-HELICAL PROTEIN [J].

BRUNET, AP ;

HUANG, ES ;

HUFFINE, ME ;

LOEB, JE ;

WELTMAN, RJ ;

HECHT, MH .

NATURE, 1993, 364 (6435) :355-358

[7]

Chou P Y, 1978, Adv Enzymol Relat Areas Mol Biol, V47, P45

[8] ENGINEERED DISULFIDE BONDS AS PROBES OF THE FOLDING PATHWAY OF BARNASE - INCREASING THE STABILITY OF PROTEINS AGAINST THE RATE OF DENATURATION [J].

CLARKE, J ;

FERSHT, AR .

BIOCHEMISTRY, 1993, 32 (16) :4322-4329

[9] THERMODYNAMICS OF PROTEIN PEPTIDE INTERACTIONS IN THE RIBONUCLEASE-S SYSTEM STUDIED BY TITRATION CALORIMETRY [J].

CONNELLY, PR ;

VARADARAJAN, R ;

STURTEVANT, JM ;

RICHARDS, FM .

BIOCHEMISTRY, 1990, 29 (25) :6108-6114

[10] THERMODYNAMIC CONSEQUENCES OF THE REMOVAL OF A DISULFIDE BRIDGE FROM HEN LYSOZYME [J].

COOPER, A ;

EYLES, SJ ;

RADFORD, SE ;

DOBSON, CM .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 225 (04) :939-943

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