INTERLEUKIN-1 CONTRIBUTES TO THE INDUCTION OF NITRIC-OXIDE SYNTHASE BY ENDOTOXIN IN-VIVO

被引：84

作者：

SZABO, C ^{[1
]}

WU, CC ^{[1
]}

GROSS, SS ^{[1
]}

THIEMERMANN, C ^{[1
]}

VANE, JR ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP, COLL MED, WILLIAM HARVEY RES INST, CHARTERHOUSE SQ, LONDON EC1M 6BQ, ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 250卷 / 01期

关键词：

ENDOTOXIN SHOCK; VASODILATATION; VASCULAR HYPOREACTIVITY; CIRCULATORY SHOCK; CYTOKINE;

D O I：

10.1016/0014-2999(93)90634-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the role of interleukin-1 in the induction of a Ca2+-independent nitric oxide (NO) synthase by bacterial endotoxin in vivo. In anaesthetized rats, pretreatment with interleukin-1 receptor antagonist (interleukin-1ra; 16 mg kg-1 i.v.. followed by an infusion of 2.4 mg kg-1 h-1) ameliorated the delayed hypotension and tachycardia in response to endotoxin (2 mg kg-1 i.v.). Endotoxaemia for 3 h induced a Ca2+-independent NO synthase activity in the lung and reduced the contractions to noradrenaline in the thoracic aorta ex vivo. Treatment with interleukin-1ra attenuated both the induction of NO synthase in the lung (by 46 +/- 5%) and the endotoxin-induced hyporeactivity to noradrenaline in the aorta. Thus, endogenous interleukin-I contributes to the induction of NO synthase in response to endotoxin in vivo.

引用

页码：157 / 160

页数：4

共 16 条

[1] INTERLEUKIN-1 INDUCES PROLONGED L-ARGININE-DEPENDENT CYCLIC GUANOSINE-MONOPHOSPHATE AND NITRITE PRODUCTION IN RAT VASCULAR SMOOTH-MUSCLE CELLS [J].

BEASLEY, D ;

SCHWARTZ, JH ;

BRENNER, BM .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) :602-608

[2] THE CYTOKINE NETWORK IN THE CRITICALLY ILL [J].

BELLOMO, R .

ANAESTHESIA AND INTENSIVE CARE, 1992, 20 (03) :288-302

[3] INDUCTION OF NITRIC-OXIDE SYNTHASE BY CYTOKINES IN VASCULAR SMOOTH-MUSCLE CELLS [J].

BUSSE, R ;

MULSCH, A .

FEBS LETTERS, 1990, 275 (1-2) :87-90

[4] MULTIPLE CYTOKINES ARE REQUIRED TO INDUCE HEPATOCYTE NITRIC-OXIDE PRODUCTION AND INHIBIT TOTAL PROTEIN-SYNTHESIS [J].

CURRAN, RD ;

BILLIAR, TR ;

STUEHR, DJ ;

OCHOA, JB ;

HARBRECHT, BG ;

FLINT, SG ;

SIMMONS, RL .

ANNALS OF SURGERY, 1990, 212 (04) :462-471

[5] BLOCKING IL-1 - INTERLEUKIN-1 RECEPTOR ANTAGONIST INVIVO AND INVITRO [J].

DINARELLO, CA ;

THOMPSON, RC .

IMMUNOLOGY TODAY, 1991, 12 (11) :404-410

[6] SYNERGISM BETWEEN INTERLEUKIN-1-BETA AND INTERFERON-GAMMA, AN INDUCER OF NITRIC-OXIDE SYNTHASE, IN RAT LUNG FIBROBLASTS [J].

JORENS, PG ;

VANOVERVELD, FJ ;

VERMEIRE, PA ;

BULT, H ;

HERMAN, AG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 224 (01) :7-12

[7] LOSS OF VASCULAR RESPONSIVENESS INDUCED BY ENDOTOXIN INVOLVES L-ARGININE PATHWAY [J].

JULOUSCHAEFFER, G ;

GRAY, GA ;

FLEMING, I ;

SCHOTT, C ;

PARRATT, JR ;

STOCLET, JC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (04) :H1038-H1043

[8] ENDOTHELIAL-CELL PRODUCTION OF NITROGEN-OXIDES IN RESPONSE TO INTERFERON-GAMMA IN COMBINATION WITH TUMOR-NECROSIS-FACTOR, INTERLEUKIN-1, OR ENDOTOXIN [J].

KILBOURN, RG ;

BELLONI, P .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (09) :772-776

[9] L-NG-NITRO ARGININE (L-NOARG), A NOVEL, L-ARGININE-REVERSIBLE INHIBITOR OF ENDOTHELIUM-DEPENDENT VASODILATATION INVITRO [J].

MOORE, PK ;

ALSWAYEH, OA ;

CHONG, NWS ;

EVANS, RA ;

GIBSON, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (02) :408-412

[10] DEXAMETHASONE PREVENTS THE INDUCTION BY ENDOTOXIN OF A NITRIC-OXIDE SYNTHASE AND THE ASSOCIATED EFFECTS ON VASCULAR TONE - AN INSIGHT INTO ENDOTOXIN-SHOCK [J].

REES, DD ;

CELLEK, S ;

PALMER, RMJ ;

MONCADA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (02) :541-547

← 1 2 →