EB-1089, A NOVEL VITAMIN-D ANALOG, HAS STRONG ANTIPROLIFERATIVE AND DIFFERENTIATION-INDUCING EFFECTS ON CANCER-CELLS

被引：113

作者：

MATHIASEN, IS ^{[1
]}

COLSTON, KW ^{[1
]}

BINDERUP, L ^{[1
]}

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT CLIN BIOCHEM,LONDON SW17 0RE,ENGLAND

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1993年 / 46卷 / 03期

关键词：

D O I：

10.1016/0960-0760(93)90226-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

EB 1089 is a novel vitamin D analogue which in vitro strongly inhibits the proliferation of U937 histiocytic lymphoma cells and MCF-7 breast cancer cells, with a potency of 50 to 100 times that of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Studies of c-myc and c-fos expression in MCF-7 cells and of differentiation markers in U937 cells show that growth inhibition by EB 1089 is accompanied by induction of differentiation. The ability of EB 1089 to affect calcium metabolism in vivo in rats is decreased, compared to 1,25(OH)2D3. This low calcemic effect combined with the strong biological effect on cancer cells in vitro, makes EB 1089 an interesting candidate for treatment of cancer.

引用

页码：365 / 371

页数：7

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