DNA FRAGMENTATION INDICATIVE OF APOPTOSIS FOLLOWING UNILATERAL CEREBRAL HYPOXIA-ISCHEMIA IN THE NEONATAL RAT

被引：146

作者：

HILL, IE ^{[1
]}

MACMANUS, JP ^{[1
]}

RASQUINHA, I ^{[1
]}

TUOR, UI ^{[1
]}

机构：

[1] NAT RES COUNCIL,INST BIODIAGNOST,WINNIPEG,MB R3B 1Y6,CANADA

来源：

BRAIN RESEARCH | 1995年 / 676卷 / 02期

关键词：

APOPTOSIS; HYPOXIA-ISCHEMIA; INTERNUCLEOSOMAL CLEAVAGE; NEONATAL; DNA DAMAGE; CELL DEATH;

D O I：

10.1016/0006-8993(95)00145-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.

引用

页码：398 / 403

页数：6

共 31 条

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