SELF-ASSEMBLY AND PHASE-BEHAVIOR OF SHORT CHAIN PHOSPHONIC ACID-WATER SYSTEMS IN A WIDE CONCENTRATION RANGE - MICROSCOPIC, NMR, AND X-RAY-DIFFRACTION STUDIES

The phase behavior of n-octane and n-hexane phosphonic acid-D//2O systems was studied in the concentration range from 0. 1 to 90 wt. % and in a temperature range from 10 degree to 130 degree C by polarizing and dark field microscopy and by **1H, **2D and, **3**1P NMR. Further, electron microscopy, X-ray diffraction and surface tension measurements were performed. For the first time, a widely spaced lamellar phase was observed over large concentration and temperature ranges in an essentially two-component system. By using the sonication or injection methods, unilamellar liposome were obtained below 1 wt. %. At high temperatures, the clouding phenomenon was observed. The importance of hydrogen bond formation between polar groups for building up stable lamellae even at high dilution is stressed. The results are discussed with respect to some existing points of view concerning the possibility of lamellar structure formation from single short chain amphiphilic compounds including lipids.