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PHOSPHOINOSITIDE INOSITOLPHOSPHOHYDROLASE OF GUINEA-PIG INTESTINAL MUCOSA

被引：80
作者：
ATHERTON, RS
HAWTHORNE, JN
机构：
[1] Department of Medical Biochemistry, Pharmacology University of Birmingham, Birmingham
来源：
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1968年 / 4卷 / 01期
关键词：
D O I：
10.1111/j.1432-1033.1968.tb00173.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some properties of the phosphoinositide inositolphosphohydrolase of guinea‐pig intestinal mucosa supernatant fraction are described. The enzyme has an absolute requirement for metal ions, the most efficient activator being Ca2+. The pH optimum is 5.3 in acetate buffer and 5.9 in maleate; activity is higher in the latter. The effects of detergents and various reagents are described. Corn phosphatidyl inositol is hydrolysed faster than brain phosphatidyl inositol; the fatty acid compositions of these lipids have been compared. The enzyme is remarkably specific for the phosphoinositides. The composition of the enzyme preparation has been studied. The enzyme appears to be widely distributed in animal tissues. Copyright © 1968, Wiley Blackwell. All rights reserved
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页码：68 / +
页数：1
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