REQUIREMENT FOR POSITIVE SELECTION OF GAMMA-DELTA-RECEPTOR-BEARING T-CELLS

被引：74

作者：

WELLS, FB

GAHM, SJ

HEDRICK, SM

BLUESTONE, JA

DENT, A

MATIS, LA

机构：

[1] NCI, FREDERICK CANC RES & DEV CTR, MOLEC IMMUNOREGULAT LAB, BIOL RESPONSE MODIFIERS PROGRAM, FREDERICK, MD 21702 USA

[2] NCI, HOWARD HUGHES MED INST, RES SCHOLARS PROGRAM, BETHESDA, MD 20892 USA

[3] UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA

[4] UNIV CALIF SAN DIEGO, CTR CANC, LA JOLLA, CA 92093 USA

[5] NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21701 USA

[6] UNIV CHICAGO, BEN MAY INST, DEPT PATHOL, COMM IMMUNOL, CHICAGO, IL 60637 USA

来源：

SCIENCE | 1991年 / 253卷 / 5022期

关键词：

D O I：

10.1126/science.1831565

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The alpha-beta and gamma-delta-T cell receptors for antigen (TCR) delineate distinct T cell populations. TCR-alpha-beta-bearing thymocytes must be positively selected by binding of the TCR to major histocompatibility complex (MHC) molecules on thymic epithelium. To examine the requirement for positive selection of TCR gamma-delta-T cells, mice bearing a class I MHC-specific gamma-delta-transgene (Tg) were crossed to mice with disrupted beta-2 microglobulin (beta-2M) genes. The Tg+beta-2M- (class I MHC-) offspring had Tg+ thymocytes that did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral Tg+ cells. This is evidence for positive selection within the gamma-delta-T cell subset.

引用

页码：903 / 905

页数：3

共 32 条

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