SOLID-PHASE SYNTHESIS AND CHARACTERIZATION OF O-DIMANNOSYLATED HEPTADECAPEPTIDE ANALOGS OF HUMAN INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)

被引：32

作者：

JANSSON, AM

MELDAL, M

BOCK, K

机构：

[1] Department of Chemistry, Carlsberg Laboratory, DK-2500 Valby, Copenhagen

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 13期

关键词：

D O I：

10.1039/p19920001699

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N(alpha)-Fmoc-3-0-[Ac4-alpha-D-Manp-(1-->2)-Ac3-alpha-D-Manp-l-]-Thr-OPfp, 7, and N(alpha)-Fmoc-3-0-[AC4-alpha-D-Manp-(1-->2)-Ac3-alpha-D-Manp-1 -]-Ser-OPfp, 8, were prepared and used as building blocks in auto-mated continuous-flow solid-phase glycopeptide synthesis of two 0-glycosylated heptadecapeptide analogues of human insulin-like growth factor 1. The corresponding non-glycosylated fragments were also prepared, and comparative NMR studies regarding the influence of the sugar moiety on the peptide backbone showed only limited effects due to glycosylation.

引用

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页码：1699 / 1707

页数：9

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