A CYTOCHEMICAL STUDY OF CEREBROVASCULAR LESIONS IN MICE INFECTED WITH PLASMODIUM-BERGHEI

被引：6

作者：

POLDER, TW ^{[1
]}

ELING, WMC ^{[1
]}

JERUSALEM, CR ^{[1
]}

WIJERSROUW, M ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN, FAC MED, DEPT CELL BIOL & HISTOL, NIJMEGEN, NETHERLANDS

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 101卷 / 01期

关键词：

MALARIA; BLOOD-BRAIN BARRIER; CYTOCHEMISTRY; ALKALINE PHOSPHATASE; ADENOSINE TRIPHOSPHATASE;

D O I：

10.1016/0022-510X(91)90015-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mice with a Plasmodium berghei infection exhibit morphological and cytochemical changes in the blood-brain barrier. Changes in activity and localization of alkaline phosphatase and adenosine triphosphatase, enzymes with important functions in the maintenance of the blood-brain barrier, were observed. Changes in activity and localization of those enzymes in and near the endothelial cells of the microvasculature, concomitant with an increase in pinocytotic activity, and formation of irregular cytoplasmic extensions in these cells, as well as loosening of the basal lamina are indicative of a functional deterioration of the blood-brain barrier in the course of infection.

引用

页码：24 / 34

页数：11

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