IMMUNOGLOBULIN ALLOTYPES ARE NOT ASSOCIATED WITH HLA-ANTIGENS, AUTOANTIBODIES AND CLINICAL SYMPTOMS IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：4

作者：

HARTUNG, K

COLDEWEY, R

ROTHER, E

PIRNER, K

SPECKER, C

SCHENDEL, D

STANGEL, W

STANNATKIESSLING, S

DELANGE, GG

机构：

[1] UNIV HANOVER,W-3000 HANNOVER,GERMANY

[2] UNIV FREIBURG,W-7800 FREIBURG,GERMANY

[3] UNIV ERLANGEN NURNBERG,W-8520 ERLANGEN,GERMANY

[4] UNIV DUSSELDORF,W-4000 DUSSELDORF 1,GERMANY

[5] UNIV BIELEFELD,W-4800 BIELEFELD,GERMANY

[6] UNIV BONN,W-5300 BONN,GERMANY

[7] UNIV MAINZ,W-6500 MAINZ,GERMANY

[8] UNIV MUNICH,W-8000 MUNICH 2,GERMANY

[9] UNIV BERN,CH-3000 BERN,SWITZERLAND

[10] UNIV ANCONA,I-60100 ANCONA,ITALY

[11] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,AMSTERDAM,NETHERLANDS

[12] UNIV AMSTERDAM,EXPTL & CLIN IMMUNOL LAB,AMSTERDAM,NETHERLANDS

来源：

RHEUMATOLOGY INTERNATIONAL | 1991年 / 11卷 / 4-5期

关键词：

IMMUNOGLOBULIN ALLOTYPES; SYSTEMIC LUPUS ERYTHEMATOSUS; GENETICS; GM; KM; HLA-ANTIGENS; AUTOANTIBODIES; CLINICAL SYMPTOMS;

D O I：

10.1007/BF00332558

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunoglobulin heavy chain (G1m, G2m, G3m, A2m) and kappa light chain (Km) allotype and phenotype frequencies of 323 central European Caucasian patients with systemic lupus erythematosus (SLE) were examined and correlated with various genetic, serologic and clinical markers of SLE. No significant associations were found between immunoglobulin allotypes or phenotypes and all 20 parameters tested (nephritis, vasculitis, arthralgias, photosensitivity, discoid lesions, central nervous system disease, Raynaud's phenomenon, sex, anti-Ro, anti-La, anti-nRNP, HLA-DR1-DR7, HLA phenotypes B8-DR3, B7-DR2). It could therefore be assumed that Gm, A2m and Km allotypes were not associated with HLA-antigens and had no influence on the serologic and clinical expression of SLE.

引用

页码：179 / 182

页数：4

共 29 条

[1] RELATIONSHIPS OF HLA-DR AND MT ANTIGENS TO AUTOANTIBODY EXPRESSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].