THE DEVELOPMENT OF MANIFEST PSORIATIC LESIONS IS LINKED WITH THE INVASION OF CD8 + T-CELLS AND CD11C + MACROPHAGES INTO THE EPIDERMIS

Koebner response was studied in 35 psoriatic patients. Two punch biopsies per patient were taken from non-lesional psoriatic skin before, and 6 h, 2 days, 7 days, 14 days and 21 days after, tape stripping. Alterations in the numbers of CD1+ Langerhans cells, CD4+ and CD8+ T cells and CD11c+ macrophages were mapped morphometrically. Results were compared with lesional and non-lesional psoriatic skin, and control skin. Nine of 35 patients were Koebner-positive. No statistically significant differences were noted between non-lesional psoriatic and control skin. CD4 + T cells increased in number 2 days after trauma in both the epidermis and the dermis, whereas epidermal CD8 + T cells and CD11c + macrophages increased only in the Koebner-positive lesional skin after 7 days. The changes in lesions induced by tape-stripping resembled those seen in lesional psoriatic skin (mature plaques). The number of CD1 + cells increased in mature psoriatic lesions only. It seems possible that trauma per se stimulates the accumulation of CD4+ T cells at the site of injury, but the development of manifest psoriatic lesions correlates with invasion of CD8 + T cells and CD11c+ macrophages into the epidermis.