TOTAL SYNTHESIS OF EPIBATIDINE

被引：74

作者：

BROKA, CA

机构：

[1] Syntex Discovery Research, Institute of Bio-Organic Chemistry, Palo Alto, CA 94304

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)73674-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes the first total synthesis of (+/-)-epibatidine (1), a putative nonopioid analgesic isolated from the skin of an Ecuadoran frog.

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收藏

页码：3251 / 3254

页数：4

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共 11 条

[1] STEREOCONTROLLED SYNTHESIS OF TROPANOL DERIVATIVES VIA PALLADIUM-CATALYZED REACTIONS
BACKVALL, JE
RENKO, ZD
BYSTROM, SE
[J]. TETRAHEDRON LETTERS, 1987, 28 (36) : 4199 - 4202
[2] A SIMPLE APPROACH TO NORTROPANE AND NORTROP-6-ENE DERIVATIVES
BATHGATE, A
MALPASS, JR
[J]. TETRAHEDRON LETTERS, 1987, 28 (47) : 5937 - 5940
[3] BOONE JR, 1979, TOP STEREOCHEM, V11, P53
[4] SYNTHESIS OF 7-AZABICYCLO 2.2.1!HEPTANE, EXO-2-CHLORO-7-AZABICYCLO 2.2.1!HEPTANE, AND DERIVATIVES
FRASER, RR
SWINGLE, RB
[J]. CANADIAN JOURNAL OF CHEMISTRY, 1970, 48 (13): : 2065 - &
[5] VINYLOGOUS PYRIDINE-CARBALDEHYDES BY WITTIG REACTION
HAGEDORN, I
HOHLER, W
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1975, 14 (07): : 486 - 486
[6] JUNG ME, 1976, TETRAHEDRON LETT, V17, P2935
[7] FACILE CONVERSION OF AZIDES TO AMINES
MAITI, SN
SINGH, MP
MICETICH, RG
[J]. TETRAHEDRON LETTERS, 1986, 27 (13) : 1423 - 1424
[8] CONJUGATE ADDITION WITH 2-PYRIDYLCOPPER AND LITHIUM 2-PYRIDYLCUPRATES
MALMBERG, H
NILSSON, M
[J]. TETRAHEDRON, 1982, 38 (10) : 1509 - 1510
[9] SYNTHESIS OF 7-AZANORBORNENE AND N-METHYL-7-AZANORBORNENE
MARCHAND, AP
ALLEN, RW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (17) : 2551 - 2552
[10] EPIBATIDINE - A NOVEL (CHLOROPYRIDYL)AZABICYCLOHEPTANE WITH POTENT ANALGESIC ACTIVITY FROM AN ECUADORIAN POISON FROG
SPANDE, TF
GARRAFFO, HM
EDWARDS, MW
YEH, HJC
PANNELL, L
DALY, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (09) : 3475 - 3478