TOTAL YIELD MEASUREMENTS IN MATRIX-ASSISTED LASER-DESORPTION USING A QUARTZ-CRYSTAL MICROBALANCE

被引：64

作者：

QUIST, AP

HUTHFEHRE, T

SUNDQVIST, BUR

机构：

[1] Division of Ion Physics, Department of Radiation Sciences, Uppsala University, Uppsala, S-751 21

[2] George Washington University, Washington, District of Columbia

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1994年 / 8卷 / 02期

关键词：

D O I：

10.1002/rcm.1290080204

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A quartz crystal microbalance (QCM) is employed to determine the desorption yield of neutral particles in matrix-assisted laser desorption ionization. For ferulic acid, the matrix substance used, the QCM mass resolution of 1 ng corresponds to a detection limit of almost-equal-to 10(12) particles. Sample exposure effects are studied at different fluences by measuring the total desorption yield after consecutive laser pulses fired on the same spot on the sample. The dependence of the total yield on the fluence is studied for different angles of incidence of the laser beam. Varying the distance between the QCM and the sample yields information about the angular spread of the desorbed neutral particles. Additional information about the fluence threshold for the production of charged particles is gained by direct electronic measurements of sample charging.

引用

页码：149 / 154

页数：6

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