DYSKERATOSIS-CONGENITA OR CHRONIC GRAFT-VERSUS-HOST DISEASE - A DIAGNOSTIC DILEMMA IN A CHILD 8 YEARS AFTER BONE-MARROW TRANSPLANTATION FOR APLASTIC-ANEMIA

被引：9

作者：

IVKER, RA ^{[1
]}

WOOSLEY, J ^{[1
]}

RESNICK, SD ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT DERMATOL,NCMH,ROOM 137,CHAPEL HILL,NC 27514

来源：

PEDIATRIC DERMATOLOGY | 1993年 / 10卷 / 04期

关键词：

D O I：

10.1111/j.1525-1470.1993.tb00400.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 12-year-old boy had striking reticulate hyperpigmentation of the neck and upper chest, dystrophic nails, patchy alopecia, and a white streak on the buccal mucosa. He was diagnosed as having chronic graft-versus-host disease (GVHD) based on clinical findings, skin biopsy findings, and his history of a bone marrow transplantation for aplastic anemia eight years earlier. Dyskeratosis congenita (DC) was not a diagnostic consideration, although the clinical findings and history of aplastic anemia made it a compelling possibility. This case highlights the clinical similarities between DC and chronic GVHD and the difficulty in arriving at an unequivocal diagnosis.

引用

页码：362 / 365

页数：4

共 14 条

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