TOWARD THE SYNTHESIS OF A 2ND-GENERATION NITROXIDE SPIN-PROBE FOR DNA DYNAMICS STUDIES

被引：13

作者：

MILLER, TR ^{[1
]}

HOPKINS, PB ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT CHEM,SEATTLE,WA 98195

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)80667-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthesis of the 2'-deoxyribonucleoside 5 is reported. This substance possesses the carbon skeleton and functional groups appropriate for the synthesis of phosphoramidite 4, which is required for the incorporation of base pair 2 into double-helical DNA. Base pair 2 is of interest as a spectroscopic probe for DNA dynamics.

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页码：981 / 986

页数：6

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