EFFECTS OF 4-HYDROXYANISOLE ON HAMSTER CHEEK POUCH

被引：12

作者：

WOODS, DA

SMITH, CJ

机构：

[1] Department of Dental Science, Royal College of Surgeons, London

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1969年 / 10卷 / 02期

关键词：

D O I：

10.1016/0014-4800(69)90033-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hamster cheek pouches were regularly treated with 4-hydroxyanisole and biopsies were taken at intervals for histology and electron microscopy. An initial erythema progressively increased and by 40 days epithelial hyperplasia and hyperkeratosis were evident, accompanied by the formation of small bullae. The epithelial-connective tissue junction was histologically disturbed and basal cells formed pseudopodia which extended through the lamina densa. Muscular degeneration also occurred. The changes in the epithelium and subepithelial connective tissue were comparable with disturbances observed in developing experimental hamster cheek pouch carcinomas. © 1969.

引用

页码：107 / &

共 9 条

[1]

ASHWORTH CT, 1961, ACTA CYTOL, V5, P369

[2] ELECTRON MICROSCOPIC STUDIES ON RELATION OF BASEMENT MEMBRANE TO SQUAMOUS CELL CARCINOMAS IN ANIMALS [J].