ENDOTHELIN STIMULATES PDGF SECRETION IN CULTURED HUMAN MESANGIAL CELLS

被引:90
作者
JAFFER, FE
KNAUSS, TC
POPTIC, E
ABBOUD, HE
机构
[1] CASE WESTERN RESERVE UNIV,DEPT MED,CLEVELAND,OH 44106
[2] VET ADM MED CTR,DEPT MED,CLEVELAND,OH 44106
关键词
D O I
10.1038/ki.1990.333
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Endothelin, a 17-DKa peptide originally described as a potent vasoconstrictor, also stimulates the release of important regulators of glomerular hemodynamics such as atrial natriuretic factor and renin. In the present study we investigated the role of endothelin in the release of another potent vasoconstrictor and mitogen of human mesangial cells, the platelet-derived growth factor. Endothelin stimulated PDGF release at 12 hours and the effect was sustained for 36 hours. This effect was associated with the enhanced induction of mRNAs encoding PDGF A- and B-chain. Endothelin also induced mitogenesis in human mesangial cells which was accompanied by activation of phospholipase C with increased inositol phosphate turnover. These data suggest a mechanism by which endothelin may regulate mesangial cell function in disease states.
引用
收藏
页码:1193 / 1198
页数:6
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