POPULATION-DYNAMICS OF HIV WITHIN AN INDIVIDUAL AFTER TREATMENT WITH ZIDOVUDINE

被引：84

作者：

MCLEAN, AR

EMERY, VC

WEBSTER, A

GRIFFITHS, PD

机构：

[1] NATL INST MED RES,MATH BIOL LAB,LONDON NW7 1AA,ENGLAND

[2] ROYAL FREE HOSP,SCH MED,DEPT VIROL,LONDON,ENGLAND

来源：

AIDS | 1991年 / 5卷 / 05期

关键词：

ZIDOVUDINE (AZT); MATHEMATICAL MODEL; POPULATION DYNAMICS; DRUG RESISTANCE;

D O I：

10.1097/00002030-199105000-00002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). Using a simple mathematical model of the interacting population dynamics of HIV and its major host cell in the circulation (the CD4 + lymphocyte), predicted patterns of HIV plasma viraemia in the weeks following treatment with zidovudine are generated. These are in close agreement with observed patterns despite the fact that the model contains no mechanisms for the development of drug-resistant strains of virus. It is suggested that the patterns of viral abundance observed during the first 6 months after treatment may be the result of non-linearities in the interactions between HIV and CD4+ cells, and that it is only after the first post-treatment burst of viral production that drug resistance plays an important role.

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页码：485 / 489

页数：5

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