BINDING OF HIV-1 GP120 TO THE NICOTINIC RECEPTOR

被引：33

作者：

BRACCI, L

LOZZI, L

RUSTICI, M

NERI, P

机构：

[1] Department of Molecular Biology, University of Siena, Policlinico Le Scotte, 53100 Siena, V. le M. Bracci

来源：

FEBS LETTERS | 1992年 / 311卷 / 02期

关键词：

ACETYLCHOLINE RECEPTOR; HIV-1; GP120; ALPHA-BUNGAROTOXIN; MIMICRY;

D O I：

10.1016/0014-5793(92)81380-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously described a significant sequence homology between HIV-1 gp120 and the functional sites responsible for the specific binding of snake curare-mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable the binding of HIV-1 gp120 to nicotinic acetylcholine receptors in muscle cells and neurons.

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页码：115 / 118

页数：4

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