MOLECULAR MODELING OF 9-AMINOELLIPTICINE INTERACTIONS WITH ABASIC OLIGONUCLEOTIDES

被引：6

作者：

LETELLIER, R

TAILLANDIER, E

BERTRAND, JR

MALVY, C

机构：

[1] UNIV PARIS 13, UFR BIOMED BOBIGNY,SPECT BIOMOLEC LAB,CNRS, URA 1430,74 RUE MARCEL CACHIN, F-93012 BOBIGNY, FRANCE

[2] INST GUSTAVE ROUSSY, BIOCHIM ENZYMOL LAB, CNRS, UA 147, INSERM, U140, F-94805 VILLEJUIF, FRANCE

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1991年 / 9卷 / 03期

关键词：

D O I：

10.1080/07391102.1991.10507938

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have used molecular mechanics to study the insertion of the DNA intercalating agent 9-aminoellipticine (9AE) into single and double stranded abasic oligonucleotides containing abasic sites in the aldose or furanose conformations. 9AE-abasic oligonucleotide complexes have been considered with 9AE bound at abasic sites as a covalent complex, a reversible complex or a Schiff base. Results are in good agreement with experimental data available on abasic oligonucleotides (melting temperature measurement, NMR results) and allow an analysis of different possible structures for 9AE-abasic oligonucleotide complexes. Hypotheses concerning the role of 9AE-abasic site complexes in enzymatic inhibition are formulated from these data.

引用

页码：579 / 597

页数：19

共 21 条

[1] OPTIMIZED PARAMETERS FOR A-DNA AND B-DNA [J].

ARNOTT, S ;

HUKINS, DWL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 47 (06) :1504-&

[2] SYNTHESIS, THERMAL-STABILITY AND REACTIVITY TOWARDS 9-AMINOELLIPTICINE OF DOUBLE-STRANDED OLIGONUCLEOTIDES CONTAINING A TRUE ABASIC SITE [J].

BERTRAND, JR ;

VASSEUR, JJ ;

RAYNER, B ;

IMBACH, JL ;

PAOLETTI, J ;

PAOLETTI, C ;

MALVY, C .

NUCLEIC ACIDS RESEARCH, 1989, 17 (24) :10307-10319

[3]

BERTRAND JR, 1989, J BIOL CHEM, V264, P14172

[4]

BINGHAM RC, 1975, J AM CHEM SOC 26, V97

[5] CONFORMATIONS OF DUPLEX STRUCTURES FORMED BY OLIGODEOXYNUCLEOTIDES COVALENTLY LINKED TO THE INTERCALATOR 2-METHOXY-6-CHLORO-9-AMINOACRIDINE [J].

CIEPLAK, P ;

RAO, SN ;

HELENE, C ;

MONTENAYGARESTIER, T ;

KOLLMAN, PA .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1987, 5 (02) :361-382

[6] AN ABASIC SITE IN DNA - SOLUTION CONFORMATION DETERMINED BY PROTON NMR AND MOLECULAR MECHANICS CALCULATIONS [J].

CUNIASSE, P ;

SOWERS, LC ;

ERITJA, R ;

KAPLAN, B ;

GOODMAN, MF ;

COGNET, JAH ;

LEBRET, M ;

GUSCHLBAUER, W ;

FAZAKERLEY, GV .

NUCLEIC ACIDS RESEARCH, 1987, 15 (19) :8003-8022

[7] THE ABASIC SITE AS A CHALLENGE TO DNA-POLYMERASE - A NUCLEAR-MAGNETIC-RESONANCE STUDY OF G, C AND T OPPOSITE A MODEL ABASIC SITE [J].

CUNIASSE, P ;

FAZAKERLEY, GV ;

GUSCHLBAUER, W ;

KAPLAN, BE ;

SOWERS, LC .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 213 (02) :303-314

[8] APURINIC SITES CAUSE MUTATIONS IN SIMIAN VIRUS-40 [J].

GENTIL, A ;

MARGOT, A ;

SARASIN, A .

MUTATION RESEARCH, 1984, 129 (02) :141-147

[9] MUTAGENESIS INVITRO BY DEPURINATION OF PHI-X174 DNA [J].

KUNKEL, TA ;

SHEARMAN, CW ;

LOEB, LA .

NATURE, 1981, 291 (5813) :349-351

[10]

← 1 2 3 →