1ST-TRIMESTER FREE-BETA (HCG) SCREENING FOR DOWN-SYNDROME

被引：54

作者：

MACRI, JN

SPENCER, K

AITKEN, D

GARVER, K

BUCHANAN, PD

MULLER, F

BOUE, A

机构：

[1] OLDCHURCH HOSP,DEPT CLIN BIOCHEM,ROMFORD RM7 0BE,ESSEX,ENGLAND

[2] DUNCAN GUTHRIE INST MED GENET,GLASGOW G38 5J,SCOTLAND

[3] W PENN HOSP,PITTSBURGH,PA 15224

[4] GENECARE MED GENET CTR,CHAPEL HILL,NC 27514

[5] INSERM,U73,F-75016 PARIS,FRANCE

[6] HOP AMBROSE PARE,F-92104 BOULOGNE,FRANCE

来源：

PRENATAL DIAGNOSIS | 1993年 / 13卷 / 07期

关键词：

FREE-BETA; MATERNAL SERUM DOWN SYNDROME SCREENING; 1ST TRIMESTER;

D O I：

10.1002/pd.1970130704

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Maternal serum free beta (hCG) levels are elevated (median 2.20 MOM) in the first trimester of pregnancy in 38 Down syndrome cases as compared with appropriate controls. This observation may form the basis for its use as a marker in screening for Down syndrome in the first trimester. Altered levels of the free beta analyte are observed in pregnancy conditions or complications other than Down syndrome.

引用

页码：557 / 562

页数：6

共 14 条

[1] HUMAN CHORIONIC-GONADOTROPIN LEVELS IN PREGNANCIES WITH ANEUPLOID FETUSES [J].