Propensity Score Method for Partially Matched Omics Studies

被引:4
作者
Kuan, Pei-Fen [1 ]
机构
[1] SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA
关键词
microarray; confounders; observational studies; full matching; regression;
D O I
10.4137/CIN.S16352
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
This paper focuses on the problem of partially matched samples in the presence of confounders. We propose using propensity score matching to adjust for confounding factors for the subset of data with incomplete pairs, followed by integrating the P-values computed from the complete and incomplete paired samples, respectively. Several simulations and a case study on DNA methylation are considered to evaluate the operating characteristics of the proposed method.
引用
收藏
页码:1 / 10
页数:10
相关论文
共 32 条
[1]
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure [J].
Alexa, Adrian ;
Rahnenfuehrer, Joerg ;
Lengauer, Thomas .
BIOINFORMATICS, 2006, 22 (13) :1600-1607
[2]
[Anonymous], GEN LINEAR MODEL
[3]
[Anonymous], 2019, TOPGO ENRICHMENT ANA
[4]
Comparing paired vs non-paired statistical methods of analyses when making inferences about absolute risk reductions in propensity-score matched samples [J].
Austin, Peter C. .
STATISTICS IN MEDICINE, 2011, 30 (11) :1292-1301
[5]
A Tutorial and Case Study in Propensity Score Analysis: An Application to Estimating the Effect of In-Hospital Smoking Cessation Counseling on Mortality [J].
Austin, Peter C. .
MULTIVARIATE BEHAVIORAL RESEARCH, 2011, 46 (01) :119-151
[6]
Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies [J].
Austin, Peter C. .
PHARMACEUTICAL STATISTICS, 2011, 10 (02) :150-161
[7]
CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[8]
Analysing and interpreting DNA methylation data [J].
Bock, Christoph .
NATURE REVIEWS GENETICS, 2012, 13 (10) :705-719
[9]
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis [J].
Du, Pan ;
Zhang, Xiao ;
Huang, Chiang-Ching ;
Jafari, Nadereh ;
Kibbe, Warren A. ;
Hou, Lifang ;
Lin, Simon M. .
BMC BIOINFORMATICS, 2010, 11
[10]
COMPARING MEANS IN PAIRED CASE WITH INCOMPLETE DATA ON BOTH RESPONSES [J].
EKBOHM, G .
BIOMETRIKA, 1976, 63 (02) :299-304