CLONING AND CHARACTERIZATION OF A NOVEL ZINC-FINGER GENE IN XP11.2

被引：19

作者：

DERRY, JMJ

JESS, U

FRANCKE, U

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,HOWARD HUGHES MED INST,STANFORD,CA 94305

[2] STANFORD UNIV,SCH MED,DEPT GENET & PEDIAT,STANFORD,CA 94305

来源：

GENOMICS | 1995年 / 30卷 / 02期

关键词：

D O I：

10.1006/geno.1995.0031

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

During a systematic search for open reading frames in chromosome band Xp11.2, a novel gene (ZNF157) that encodes a putative 506-amino-acid protein with the sequence characteristics of a zinc-finger-containing transcription factor was isolated. ZNF157 is encoded by four exons distributed over >20 kb of genomic DNA. The second and third exons contain sequences similar to those of the previously described KRAB-A and KRAB-B domains, motifs that have been shown to mediate transcriptional repression in other members of the protein family. A fourth exon contains 12 zinc finger DNA binding motifs and finger linking regions characteristic of ZNF proteins of the Kruppel family. ZNF157 maps to the telomeric end of a cluster of ZNF genes that includes ZNF21, ZNF41, and ZNF81. (C) 1995 Academic Press, Inc.

引用

页码：361 / 365

页数：5

共 19 条

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