PREOPTIC UNIT RESPONSES TO MICROELECTROPHORESIS OF NEUROTENSIN AND ITS ANTISERUM IN FEMALE RATS

被引：1

作者：

AKEMA, T ^{[1
]}

KIMURA, F ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT PHYSIOL,YOKOHAMA,KANAGAWA 232,JAPAN

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 1990年 / 2卷 / 02期

关键词：

antiserum; female rat; medial preoptic area; neurotensin; unit activity;

D O I：

10.1111/j.1365-2826.1990.tb00843.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We and other investigators have demonstrated the stimulation of luteinizing hormone secretion following the microinjection of neurotensin (NT) into the medial preoptic area in female rats. The present study electrophysiologically examined the action of the peptide in the same brain region. Microelectrophoresis of NT produced either excitation or inhibition in 24% of the medial preoptic neurons tested in oestrogen‐primed and unprimed ovariectomized animals. Effective blockade of NT‐induced excitatory and inhibitor unit responses by means of the simultaneous application of an antiserum to NT (anti‐NT) indicated that they were produced by specific actions of the peptide. In addition, anti‐NT by itself altered the spontaneous firing rate in some NT‐responsive cells. These findings are in accord with the hypothesis that the preoptic area is a site of the action of NT in the female rat. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：141 / 143

页数：3

共 19 条

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