ROLE OF VASOCONSTRICTOR MECHANISMS IN THE CONTROL OF LEFT-VENTRICULAR PERFORMANCE OF THE NORMAL AND DAMAGED HEART

被引：44

作者：

COHN, JN

MASHIRO, I

LEVINE, TB

MEHTA, J

机构：

[1] Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1979年 / 44卷 / 05期

关键词：

D O I：

10.1016/0002-9149(79)90238-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect on the left ventricle of changes in the state of the arterial vasculature is best identified by utilizing calculations of pulsatile rather than steady flow phenomena. Impedance is the most satisfactory term to describe this effect. The normal ventricle compensates for changes in impedance largely by changes in preload, but the damaged heart loses this compensatory ability and its stroke volume becomes inversely related to outflow resistance. Patients with heart failure behave in a similar fashion and pharmacologic vasodilation may induce marked improvement in left ventricular pump function. Inappropriate vasoconstriction in heart failure may result from stimulation of the sympathetic or renin-angiotensin system. Early experience with converting enzyme inhibitors suggests that blockade of the formation of angiotensin II may be a useful means of treating some patients with heart failure. © 1979.

引用

页码：1019 / 1022

页数：4

共 13 条

[1]

COHN J N, 1973, Circulation, V48, P5

[2] ROLE OF RENIN-ANGIOTENSIN SYSTEM IN SYSTEMIC VASOCONSTRICTION OF CHRONIC CONGESTIVE HEART-FAILURE [J].